Safety and efficacy of azathioprine in the maintenance of ciclosporin-induced remission of ulcerative colitis

Citation
Gc. Actis et al., Safety and efficacy of azathioprine in the maintenance of ciclosporin-induced remission of ulcerative colitis, ALIM PHARM, 15(9), 2001, pp. 1307-1311
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology,"da verificare
Journal title
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
ISSN journal
0269-2813 → ACNP
Volume
15
Issue
9
Year of publication
2001
Pages
1307 - 1311
Database
ISI
SICI code
0269-2813(200109)15:9<1307:SAEOAI>2.0.ZU;2-E
Abstract
Background: It has been shown that azathioprine prolongs the response to ci closporin of steroid-refractory ulcerative colitis, but no specific data ar e available concerning its toxicity in this indication. Aim and methods: The charts of 21 patients with steroid-refractory ulcerati ve colitis who received azathioprine overlapping with a successful ciclospo rin course were reviewed for the onset of toxicity. The controls consisted of 48 initial responders to steroids who received azathioprine for steroid- dependence or resistance/toxicity. Results: Two of the 21 patients were withdrawn because of hypersensitivity to azathioprine. The remaining 19 were treated for a median of 18 months to gether with a median daily steroid dose of 35 mg: (10-75 mg) to be tapered off. Toxicity (31%) included leukopenia alone (two cases), cholestasis alon e (one case), cholestasis and increased amylase (one case), increased amyla se alone (one case), and cutaneous infection (one case). The frequency of w ithdrawal was 21%. The mean daily steroid doses were reduced from 38 mg to 3.8 mg in the study cohort, and from 25 mg: to 8 mg in the controls, among whom toxicity (27%) included four cases each of leukopenia and increased am ylase, two cases each of alteration of liver enzymes and infection, and one case of gastric intolerance. Ten of the 48 controls (20%) were withdrawn f rom the study. Conclusion: Azathioprine is as effective and safe in the maintenance of the response of patients with steroid-refractory ulcerative colitis to ciclosp orin as it is in the treatment of those who respond to steroids.