Review article: pathogenesis of Helicobacter pylori-induced gastric inflammation

Citation
Da. Israel et Rm. Peek, Review article: pathogenesis of Helicobacter pylori-induced gastric inflammation, ALIM PHARM, 15(9), 2001, pp. 1271-1290
Citations number
228
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Pharmacology,"da verificare
Journal title
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
ISSN journal
0269-2813 → ACNP
Volume
15
Issue
9
Year of publication
2001
Pages
1271 - 1290
Database
ISI
SICI code
0269-2813(200109)15:9<1271:RAPOHP>2.0.ZU;2-#
Abstract
Helicobacter pylori causes persistent inflammation in the human stomach, ye t only a minority of persons harbouring this organism develop peptic ulcer disease or gastric malignancy. An important question is why such variation exists among colonized individuals. Recent evidence has demonstrated that H , pylori isolates possess substantial phenotypic and genotypic diversity, w hich may engender differential host inflammatory responses that influence c linical outcome. For example, H. pylori strains that possess the cag pathog enicity island induce more severe gastritis and augment the risk for develo ping peptic ulcer disease and distal gastric cancer. An alternative, but no t exclusive, hypothesis is that enhanced inflammation and injury is a conse quence of an inappropriate host immune response to the chronic presence of H. pylori within the gastric niche. Investigations that precisely delineate the mechanisms responsible for induction of gastritis will ultimately help to define which H. pylori-colonized persons bear the highest risk for subs equent development of clinical disease, and thus, enable physicians to focu s eradication therapy.