Pathological and immunohistochemical study of the abomasum and abomasal lymph nodes in goats experimentally infected with Haemonchus contortus

Citation
J. Perez et al., Pathological and immunohistochemical study of the abomasum and abomasal lymph nodes in goats experimentally infected with Haemonchus contortus, VET RES, 32(5), 2001, pp. 463-473
Citations number
35
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Veterinary Medicine/Animal Health
Journal title
VETERINARY RESEARCH
ISSN journal
0928-4249 → ACNP
Volume
32
Issue
5
Year of publication
2001
Pages
463 - 473
Database
ISI
SICI code
0928-4249(200109/10)32:5<463:PAISOT>2.0.ZU;2-B
Abstract
Histopathological changes and the distributions of T and B lymphocytes and IgG producing plasma cells were recorded in the abomasum and abomasal lymph nodes of goats 3, 7 and 21 weeks post-infection (wpi) after an experimenta l infection with H. contortus. The low rate of worm recovery by 3 wpi (5.6% ) might have been due to larvae death as suggested by the presence of granu lomas in the abomasal mucosa at 3 and 7 wpi, or simply due to a poor larval establishment. Marked increase in the secretion of mucus by mucous cells t ogether with an abundant infiltration of eosinophils, mast cells, CD3(+) T lymphocytes, CD79a(+) B cells, IgG(+) plasma cells and globule leukocytes w ere recorded in the abomasal mucosa, especially at 7 wpi. Except for the gl obule leukocytes, this reaction decreased substantially by week 21, suggest ing this cell type may have been involved in rejection of adult nematodes. The abomasal lymph nodes showed marked hyperplasia, particularly of CD79a() B cells and IgG(+) plasma cells in all infected goats. These reactions ma y have been responsible for the reduction in the number of worms found in t he abomasum between 3 and 7 wpi.