A novel sterol from Chinese truffles Tuber indicum

Gao, JM Hu, L Liu, JK

Jm. Gao et al., A novel sterol from Chinese truffles Tuber indicum, STEROIDS, 66(10), 2001, pp. 771-775

14

INGLESE

Article

Biochemistry & Biophysics

STEROIDS

0039-128X → ACNP

66

10

2001

771 - 775

ISI

0039-128X(200110)66:10<771:ANSFCT>2.0.ZU;2-N

From the fruiting bodies of Ascomycetes Tuber indicum, a new steroidal gluc oside with polyhydroxy ergosterol nucleus, tuberoside (2), has been isolate d along with additional four known ergosterol derivatives, (22E, 24R)-ergos ta-7, 22-dien-3 beta, 5 alpha, 6 beta -triol (1), 5 alpha, 8 alpha -epidiox y-(22E, 24R)-ergosta-6, 22-dien-3 beta -ol (3), (22E, 24R)-ergosta-5, 22-di en-3 beta -ol (4), and (22E, 24R)-ergosta-4, 6, 8(14), 22-tetraen-3-one (5) . The structure of new compound was established as 3-O-beta -D-glucopyranos yl-(22E, 24R)-ergosta-7, 22-dien-5 alpha, 6 beta -diol (2) on the basis of chemical and spectroscopic means (H-1 NNM, C-13 NMR, HMQC, HMBC, MS, and IR ). This is the first example of isolation of a polyhydroxylated ergosterol glucoside from higher fungi in nature. (C) 2001 Elsevier Science Inc. All r ights reserved.