Characteristics of incisor-premolar hypodontia in families

Citation
S. Arte et al., Characteristics of incisor-premolar hypodontia in families, J DENT RES, 80(5), 2001, pp. 1445-1450
Citations number
29
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Dentistry/Oral Surgery & Medicine","da verificare
Journal title
JOURNAL OF DENTAL RESEARCH
ISSN journal
0022-0345 → ACNP
Volume
80
Issue
5
Year of publication
2001
Pages
1445 - 1450
Database
ISI
SICI code
0022-0345(200105)80:5<1445:COIHIF>2.0.ZU;2-B
Abstract
Nonsyndromic tooth agenesis is a genetically and phenotypically heterogenou s condition. It is generally assumed that different phenotypic forms are ca used by different mutated genes. We analyzed inheritance and phenotype of h ypodontia and dental anomalies in 214 family members in three generations o f 11 probands collected for genetic linkage study on incisor-premolar hypod ontia (IPH), Our analysis confirms the autosomal-dominant transmission with reduced penetrance of IPH. The prevalence of hypodontia and/or peg-shaped teeth was over 40% in first and second-degree relatives and 18% in first co usins of the probands. Four of nine noted obligate carriers of hypodontia g ene had dental anomalies, including small upper lateral incisors, ectopic c anines, taurodontism, and rotated premolars. These anomalies were also obse rved at higher than normal frequency in relatives affected with hypodontia. We conclude that incisor premolar hypodontia is a genetic condition with a utosomal-dominant transmission and that it is associated with several other dental abnormalities.