Thymidine phosphorylase (TP) is an enzyme which converts doxifluridine (5 '
-DFUR) to 5-fluorouracil (5-FU). To assess whether TP expression is useful
for selecting adjuvant chemotherapy in advanced gastric cancer, we compare
d effects of oral 5 ' -DFUR and 5-FU and assessed correlation between drug
efficacy and TP expression level. We examined TP expression in 286 patients
. TP expression was assessed with immunohistochemical staining. When we com
pared prognosis in two chemotherapy groups with high TP expression, better
survival was observed in 5 ' -DFUR than in 5-FU group (p=0.0413). Especiall
y in stage III, patients with high TP had better survival in 5 ' -DFUR than
in 5-FU group.