Thymidine phosphorylase expression is useful in selecting adjuvant chemotherapy for stage III gastric cancer

Citation
R. Ishii et al., Thymidine phosphorylase expression is useful in selecting adjuvant chemotherapy for stage III gastric cancer, INT J ONCOL, 19(4), 2001, pp. 717-722
Citations number
41
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
INTERNATIONAL JOURNAL OF ONCOLOGY
ISSN journal
1019-6439 → ACNP
Volume
19
Issue
4
Year of publication
2001
Pages
717 - 722
Database
ISI
SICI code
1019-6439(200110)19:4<717:TPEIUI>2.0.ZU;2-Y
Abstract
Thymidine phosphorylase (TP) is an enzyme which converts doxifluridine (5 ' -DFUR) to 5-fluorouracil (5-FU). To assess whether TP expression is useful for selecting adjuvant chemotherapy in advanced gastric cancer, we compare d effects of oral 5 ' -DFUR and 5-FU and assessed correlation between drug efficacy and TP expression level. We examined TP expression in 286 patients . TP expression was assessed with immunohistochemical staining. When we com pared prognosis in two chemotherapy groups with high TP expression, better survival was observed in 5 ' -DFUR than in 5-FU group (p=0.0413). Especiall y in stage III, patients with high TP had better survival in 5 ' -DFUR than in 5-FU group.