Stiff-person syndrome associated with cerebellar ataxia and high glutamic acid decarboxylase antibody titer

Citation
S. Kono et al., Stiff-person syndrome associated with cerebellar ataxia and high glutamic acid decarboxylase antibody titer, INTERN MED, 40(9), 2001, pp. 968-971
Citations number
9
Language
INGLESE
art.tipo
Article
Categorie Soggetti
General & Internal Medicine
Journal title
INTERNAL MEDICINE
ISSN journal
0918-2918 → ACNP
Volume
40
Issue
9
Year of publication
2001
Pages
968 - 971
Database
ISI
SICI code
0918-2918(200109)40:9<968:SSAWCA>2.0.ZU;2-9
Abstract
Glutamic acid decarboxylase (GAD) is the main target of humoral autoimmunit y in patients with insulin-dependent diabetes mellitus (IDDM) and stiff-per son syndrome. We reviewed the case of a 46-year-old woman who had cerebella r ataxia before getting stiff-person syndrome and IDDM with high anti-GAD a utoantibody titers. This was a rare case in which there were both the clini cal symptoms of stiff-person syndrome and cerebellar ataxia. In western blo t analysis her serum reacted with 65-kDa proteins from rat cerebellum, cere bral cortex, and spinal cord. Autoantibodies to GAD may cause functional im pairment of gamma -aminobutyric acid (GABA) neurons in the spinal cord as w ell as in the cerebellum.