Renal cell carcinoma with skull base metastasis preceded by paraneoplasticsigns in a chronic hemodialysis patient

Citation
K. Endo et al., Renal cell carcinoma with skull base metastasis preceded by paraneoplasticsigns in a chronic hemodialysis patient, INTERN MED, 40(9), 2001, pp. 924-930
Citations number
27
Language
INGLESE
art.tipo
Article
Categorie Soggetti
General & Internal Medicine
Journal title
INTERNAL MEDICINE
ISSN journal
0918-2918 → ACNP
Volume
40
Issue
9
Year of publication
2001
Pages
924 - 930
Database
ISI
SICI code
0918-2918(200109)40:9<924:RCCWSB>2.0.ZU;2-G
Abstract
A 59-year-old man who had received chronic hemodialysis developed left occi pital pain and hypoglossal nerve palsy. He was diagnosed as having skull ba se metastasis from renal cell carcinoma related to acquired cystic kidney. Retrospective analysis revealed the patient had had elevated serum C-reacti ve protein and alkaline phosphatase levels before the symptoms appeared. Ra diotherapy to the skull base relieved the pain. Finally he died with genera lized metastases. Serum interleukin-6 levels measured during admission had been elevated, and interleukin-6 mRNA was detected in the autopsy specimen of renal cell carcinoma. Interleukin-6 might be involved in the etiology of paraneoplastic signs.