Various scoring systems evaluating histologic features of chronic hepatitis C treated with interferon

Citation
H. Ikawa et al., Various scoring systems evaluating histologic features of chronic hepatitis C treated with interferon, HUMAN PATH, 32(9), 2001, pp. 910-917
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research Diagnosis & Treatment
Journal title
HUMAN PATHOLOGY
ISSN journal
0046-8177 → ACNP
Volume
32
Issue
9
Year of publication
2001
Pages
910 - 917
Database
ISI
SICI code
0046-8177(200109)32:9<910:VSSEHF>2.0.ZU;2-C
Abstract
Various scoring systems for chronic hepatitis have been proposed, however, there is no standard scoring system for studies of interferon (IFN) therapy in patients with chronic hepatitis C. The aims of this study were to deter mine the most useful system reflecting histologic changes in biopsy specime ns from complete responders and predicting the efficacy of IFN therapy. Pat ients with chronic hepatitis C were administered IFN-alpha for 6 months. Fo rty-six patients were included in this study and categorized as complete re sponders (n = 15), partial responders (n = 24), and nonresponders (n = 7) a ccording to viral and biochemical responses to the therapy. Biopsy specimen s obtained from each patient before and after treatment were evaluated unde r 3 different systems: Histological Activity Index (HAI), modified HAI, and Scheuer classification. Complete responders showed considerable improvemen t in both grade and stage on the modified FLU and Scheuer classifications. On the HAI, a considerable improvement was observed in grade but not in sta ge. No significant change was observed in partial responders or nonresponde rs on any system. Prediction of complete response was not possible under an y system, but the pretreatment score reflecting piecemeal necrosis on any 1 of the 3 classifications and the fibrosis score on Scheuer classification were predictors of nonresponse. The modified HAI system and Scheuer classif ication were amply useful in evaluating histologic changes in complete resp onders. Scores higher than 4 of the categories reflecting piecemeal necrosi s on any system and fibrosis scores of 3 or 4 on Scheuer classification pre dicted nonresponse to IFN therapy. Copyright (C) 2001 by W.B. Saunders Comp any.