Effect of salbutamol on lung function parameters of healthy children

Citation
K. Delanghe et al., Effect of salbutamol on lung function parameters of healthy children, EUR J PED, 160(9), 2001, pp. 576-578
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pediatrics,"Medical Research General Topics
Journal title
EUROPEAN JOURNAL OF PEDIATRICS
ISSN journal
0340-6199 → ACNP
Volume
160
Issue
9
Year of publication
2001
Pages
576 - 578
Database
ISI
SICI code
0340-6199(200109)160:9<576:EOSOLF>2.0.ZU;2-C
Abstract
In the present study, the effect of 200 mug salbutamol compared to placebo was evaluated on lung function parameters of 37 healthy children aged 7-14 years. Salbutamol or placebo were administered, using a single blind study design, and spirometry was performed before and after 10 min of inhalation. At the time of the study, all children were symptom-free and had not suffe red from any respiratory infection during the previous 4 weeks. The adminis tration of salbutamol resulted in a significant increase of mean forced exp iratory volume in 1 s (111%-115%, P < 0.05), maximal expiratory flow at 50% of forced vital capacity (101%-110%, P < 0.05) and maximal expiratory flow at 25 % of forced vital capacity (96%-115%, P < 0.05). The administration of placebo resulted in no significant change in lung function parameters. C onclusion: The administration of 200 mug salbutamol results in the occurren ce of a small but significant bronchodilation in healthy, non-asthmatic chi ldren.