Children with epilepsy after withdrawal of anticonvulsive therapy: psychiatric behaviour and neuropsychological abilities

Citation
W. Kolfen et al., Children with epilepsy after withdrawal of anticonvulsive therapy: psychiatric behaviour and neuropsychological abilities, EUR J PED, 160(9), 2001, pp. 566-571
Citations number
27
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pediatrics,"Medical Research General Topics
Journal title
EUROPEAN JOURNAL OF PEDIATRICS
ISSN journal
0340-6199 → ACNP
Volume
160
Issue
9
Year of publication
2001
Pages
566 - 571
Database
ISI
SICI code
0340-6199(200109)160:9<566:CWEAWO>2.0.ZU;2-B
Abstract
Do children who remain in remission with epilepsy after withdrawal of antic onvulsive therapy still exhibit a different behaviour and performance-relat ed abilities compared to healthy children? It was the aim of this study to investigate whether these children showed deviating psychiatric behaviour a nd/or neuropsychological function deficits as compared with a healthy contr ol group and with children following occasional seizures which had never be en treated. The study comprised 39 children with epilepsy after withdrawal of anticonvulsive therapy, 37 children with occasional seizures, and 39 mat ched healthy control children who were tested with regard to psychiatric an d neuropsychological criteria. The patients were aged 6-15 years; 28 bad a primarily generalised epilepsy, and I I had a focal epilepsy. The patients remained free from seizures for more than 1 year. Psychiatric testing compr ised the Child Behavior Checklist by Achenbach and Edelbrock [1] and the Ma nnheim Parent Interview. Neuropsychological testing included non-verbal int elligence, visual perception, short-term memory and learning ability, arith metics, movement coordination and motor skills, fine motor skills and verba l functions. After withdrawal from anticonvulsive therapy, the children wit h epilepsy did not exhibit any psychiatric disturbances, whereas those with occasional seizures frequently showed behaviour problems. After withdrawal from anticonvulsive therapy, no neuropsychological deficits were found in the children with epilepsy as compared to those with occasional seizures or to healthy children. Risk factors for poorer test results were first seizu res occurring before the age of 3 years, delayed development, and neonatal problems. Conclusion: Children with epilepsy who remained without relapse a fter withdrawal from the anticonvulsive therapy did not show any psychiatri c abnormalities and their performance was comparable to that of healthy con trol children, provided no risk factors were present.