Molecular and genomic characterization of human DLEC, a novel member of the C-type lectin receptor gene family preferentially expressed on monocyte-derived dendritic cells

Citation
I. Arce et al., Molecular and genomic characterization of human DLEC, a novel member of the C-type lectin receptor gene family preferentially expressed on monocyte-derived dendritic cells, EUR J IMMUN, 31(9), 2001, pp. 2733-2740
Citations number
29
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
EUROPEAN JOURNAL OF IMMUNOLOGY
ISSN journal
0014-2980 → ACNP
Volume
31
Issue
9
Year of publication
2001
Pages
2733 - 2740
Database
ISI
SICI code
0014-2980(200109)31:9<2733:MAGCOH>2.0.ZU;2-P
Abstract
We have identified a novel gene encoding a protein designated DLEC (dendrit ic cell lectin), which is a type II membrane glycoprotein of 213 amino acid s and belongs to the human calcium-dependent (C-type) lectin family. The cy toplasmic tail of DLEC lacks consensus signaling motifs and its extracellul ar region shows a single carbohydrate recognition domain (CRD), closest in homology to the dendritic cell immunoreceptor (DCIR) CRD. The DLEC gene has been localized linked to DCIR on the telomeric region of the NK gene compl ex. RT-PCR and Northern blot analyses show that DLEC mRNA is preferentially expressed in monocyte-derived dendritic cells.