Differential recruitment of accessory molecules by Fc gamma RI during monocyte differentiation

Citation
Ajm. Cameron et al., Differential recruitment of accessory molecules by Fc gamma RI during monocyte differentiation, EUR J IMMUN, 31(9), 2001, pp. 2718-2725
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
EUROPEAN JOURNAL OF IMMUNOLOGY
ISSN journal
0014-2980 → ACNP
Volume
31
Issue
9
Year of publication
2001
Pages
2718 - 2725
Database
ISI
SICI code
0014-2980(200109)31:9<2718:DROAMB>2.0.ZU;2-2
Abstract
Aggregation of the human high-affinity receptor for immunoglobulin G, Fc ga mma RI, results in initiation of intracellular signaling cascades. However, as the receptor contains no known signaling motif, it is required to recru it an accessory molecule. The gamma chain has been proposed to fulfil this role. Here, we show that in U937 cells differentiated to a more macrophage- like phenotype with dibutyryl cAMP Fc gamma RI no longer signals through th e gamma chain but rather uses Fc gamma IIa to initiate tyrosine phosphoryla tion. Expression of the gamma chain is, however, increased in the dbcAMP-in duced cells, but here the gamma chain specifically associates with the IgA receptor, Fc alpha RI Recruitment of the gamma chain either by Fc gamma RI in cytokine-primed cells or by Fc alpha RI in dbcAMP-induced cells couples ligand binding to the activation of phosphatidyl choline-specific phospholi pase D.