Maternal kappa-containing IgG induces a late anti-kappa response in adult,kappa-deficient offspring

Citation
O. Bengtsson et al., Maternal kappa-containing IgG induces a late anti-kappa response in adult,kappa-deficient offspring, EUR J IMMUN, 31(9), 2001, pp. 2652-2659
Citations number
40
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
EUROPEAN JOURNAL OF IMMUNOLOGY
ISSN journal
0014-2980 → ACNP
Volume
31
Issue
9
Year of publication
2001
Pages
2652 - 2659
Database
ISI
SICI code
0014-2980(200109)31:9<2652:MKIIAL>2.0.ZU;2-A
Abstract
Kappa (kappa)-light (L) chain-deficient (C kappa-/-) mice readily mount a T cell-dependent antibody response after immunization with kappa -containing proteins. Such antibody responses are absent in normal (C kappa+/+) animal s because of tolerance due to the abundance of kappa -L chains expressed on more than 95% of all B cells and serum immunogiobulins. When heterozygous ic-sufficient (C kappa+/-) females are bred with homozygous; kappa -deficie nt (C kappa-/-) males, half of their offspring will become kappa -deficient but have received kappa -L chain containing maternal Ig, mainly IgG and Ig A, through placental and intestinal transmission. The kappa -containing mat ernal Ig persists for more than 2 months in the circulation of the offsprin g. Starting from week 15-20 of age, a spontaneous antibody response towards the maternal kappa -L chains can be recorded. The time of onset, as well a s the magnitude of the responses differ among individuals of the same litte r. Invariably, once a response has been initiated, it transits into an IgGt ype of response, which upon injection with kappa -containing protein shows the features of a secondary type of immune response.