Differential migration of in vivo primed B and T lymphocytes to lymphoid and non-lymphoid organs

Citation
D. Finke et H. Acha-orbea, Differential migration of in vivo primed B and T lymphocytes to lymphoid and non-lymphoid organs, EUR J IMMUN, 31(9), 2001, pp. 2603-2611
Citations number
51
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
EUROPEAN JOURNAL OF IMMUNOLOGY
ISSN journal
0014-2980 → ACNP
Volume
31
Issue
9
Year of publication
2001
Pages
2603 - 2611
Database
ISI
SICI code
0014-2980(200109)31:9<2603:DMOIVP>2.0.ZU;2-P
Abstract
Our study describes tissue-specific migration of T and B cells during a loc alized anti-viral immune response. After mouse mammary tumor virus (MMTV) i njection, B. lymphocytes of the draining lymph node become infected and pre sent a retroviral superantigen to CD4(+) T lymphocytes. Infected B cells re ceive superantigen-mediated help in a fashion comparable to classical immun e responses. To investigate the fate of T and B lymphocytes that had intera cted via cognate help in the same peripheral lymph node microenvironment we adoptively transferred them into naive recipients. Here we show that MMTV- infected B cells and superantigen-stimulated T cells were programmed to mig rate to distinct sites of the body. Plasmablasts but not T cells migrated t o the mammary gland and activated alpha4 beta1 integrins were found to have a crucial role in the migration to the mammary gland. In contrast, T cells had a much higher affinity for secondary lymphoid organs and large intesti ne. This demonstrates that upon antigen-driven B and T lymphocyte interacti on in the local draining lymph node a subset-specific homing program for B and T lymphocytes is induced.