Inhibition of tumor necrosis factor reduces the severity of virus-specificlung immunopathology

Citation
T. Hussell et al., Inhibition of tumor necrosis factor reduces the severity of virus-specificlung immunopathology, EUR J IMMUN, 31(9), 2001, pp. 2566-2573
Citations number
43
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
EUROPEAN JOURNAL OF IMMUNOLOGY
ISSN journal
0014-2980 → ACNP
Volume
31
Issue
9
Year of publication
2001
Pages
2566 - 2573
Database
ISI
SICI code
0014-2980(200109)31:9<2566:IOTNFR>2.0.ZU;2-L
Abstract
TNF antagonists are effective treatments for rheumatoid arthritis and Crohn 's disease, and have been tried with variable success in other diseases cau sed by immune damage. To test the hypothesis that viral lung. diseases caus ed by respiratory syncytial virus or influenza virus are partly due to over production of TNF, we used anti-TNF antibody to treat mice With-lung diseas e caused by these viruses. TNF depletion reduced pulmonary recruitment of i nflammatory cells, cytokine production by T cells and the severity of illne ss Without preventing virus clearance. These broad beneficial effects sugge st that TNF antagonists might be tested as treatments of human viral lung d iseases.