The prognostic and predictive values of ECD-HER-2

Authors
Citation
Wn. Hait, The prognostic and predictive values of ECD-HER-2, CLIN CANC R, 7(9), 2001, pp. 2601-2604
Citations number
36
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
Journal title
CLINICAL CANCER RESEARCH
ISSN journal
1078-0432 → ACNP
Volume
7
Issue
9
Year of publication
2001
Pages
2601 - 2604
Database
ISI
SICI code
1078-0432(200109)7:9<2601:TPAPVO>2.0.ZU;2-#
Abstract
The search for a simple, sensitive test to reliably determine prognosis and predict response to therapy in patients with cancer is an important area o f translational research. In this issue of Clinical Cancer Research, Hayes et al. (Clin. Cancer Res., 7: 2703-2710, 2001) report the results of an anc illary Cancer and Leukemia Group B protocol designed to determine whether t he circulating extracellular domain of HER-2/neu (ECD-HER-2) was indicative of prognosis or predictive of response to therapy in women with metastatic breast cancer. Results were drawn from a sample of 242 patients of whom 89 had elevated values of the protein. These women had been enrolled in a var iety of Cancer and Leukemia Group B protocols evaluating either the efficac y of dose in the use of megestrol acetate as second-line hormonal treatment or in patients enrolled into several chemotherapeutic protocols, many cont aining doxorubicin. They report that patients with pretreatment elevation o f ECD-HER-2 had a worse prognosis than those who did not, but that there wa s no convincing correlation of elevated ECD-HER-2 with response to either e ndocrine or chemotherapy. Although the small number of patients and the ret rospective study design allows one to draw only tentative conclusions, this report raises several important issues for the conduct of translational re search and points to several new hypotheses for future testing.