Hepatitis c viral RNA: challenges and promises

Authors
Citation
St. Shi et Mmc. Lai, Hepatitis c viral RNA: challenges and promises, CELL MOL L, 58(9), 2001, pp. 1276-1295
Citations number
236
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELLULAR AND MOLECULAR LIFE SCIENCES
ISSN journal
1420-682X → ACNP
Volume
58
Issue
9
Year of publication
2001
Pages
1276 - 1295
Database
ISI
SICI code
1420-682X(200108)58:9<1276:HCVRCA>2.0.ZU;2-G
Abstract
Hepatitis C virus (HCV), a positive-sense, single-stranded RNA virus of the Flaviviridae family, is a major cause of chronic hepatitis, liver cirrhosi s, and hepatocellular carcinoma worldwide. Its RNA is difficult to study be cause biological materials are scarce and RNA replication is of low efficie ncy. This review focuses on the structure and functions of HCV RNA along wi th their biological and clinical significance. Despite the challenging char acteristics of HCV significant progress has been made in understanding the properties of HCV RNA and developing viral replication systems toward the i mprovement of antiviral therapies.