Pre-menstrual steroids

Authors
Citation
Ss. Smith, Pre-menstrual steroids, CELL MOL L, 58(9), 2001, pp. 1263-1275
Citations number
122
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELLULAR AND MOLECULAR LIFE SCIENCES
ISSN journal
1420-682X → ACNP
Volume
58
Issue
9
Year of publication
2001
Pages
1263 - 1275
Database
ISI
SICI code
1420-682X(200108)58:9<1263:PS>2.0.ZU;2-9
Abstract
A number of steroid hormones and their metabolites fluctuate in the circula tion across the human menstrual cycle. In addition to their classic actions on the hypothalamo-pituitary-gonadal axis, many of these hormones act as ' neuroactive steroids' to alter the function of neurotransmitters, such as G ABA, within central nervous system circuits. Clinically, these steroids are important because they have not only acute but also long-term effects, and 'withdrawal' properties. This review discusses the effects of steroids suc h as 3 alpha -OH-5 alpha -pregnan-20-one (3 alpha ,5 alpha -THP or allopreg nanolone) which alter GABA function in distinct ways dependent upon the tim e course of exposure, to either enhance or decrease inhibition in the brain . These effects are discussed in light of recent clinical findings which se ek to further characterize the steroid milieu which underlies pre-menstrual dysphoria.