Variable effects of nitrous oxide at multiple levels of the central nervous system in goats

Citation
Jf. Antognini et al., Variable effects of nitrous oxide at multiple levels of the central nervous system in goats, VET RES COM, 25(7), 2001, pp. 523-538
Citations number
39
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Veterinary Medicine/Animal Health
Journal title
VETERINARY RESEARCH COMMUNICATIONS
ISSN journal
0165-7380 → ACNP
Volume
25
Issue
7
Year of publication
2001
Pages
523 - 538
Database
ISI
SICI code
0165-7380(200110)25:7<523:VEONOA>2.0.ZU;2-V
Abstract
The direct and indirect effects of nitrous oxide (N2O) on the nociceptive r esponses of lumbar dorsal horn neurons, and the indirect effects on midbrai n reticular formation (MRF) neurons and thalamic neurons were determined in goats anaesthetized with isoflurane. The technique used enabled the differ ential delivery of N2O to either the torso or the cerebral circulation, thu s allowing assessment of the direct spinal and indirect brain effects of N2 O. Systemic delivery of N2O appeared to have divergent effects, facilitatin g (4/11) or depressing (7/11) the responses of dorsal horn neurons. Such di vergent effects were also observed when N2O was differentially delivered to the circulation in the torso (i.e. the spinal cord). Likewise, MRF and tha lamic responses to noxious stimulation were variably affected by administra tion of N2O to the torso, with some cells facilitated (7/13 MRF neurons, 3/ 8 thalamic neurons) and others depressed (6/13 MRF neurons, 5/8 thalamic ne urons). It appears that N2O has variable effects on the caprine CNS. The fa cilitatory action of N2O might partially explain why it is a relatively wea k anaesthetic.