Enhanced platelet aggregation in the coronary circulation after coronary spasm

Citation
S. Miyamoto et al., Enhanced platelet aggregation in the coronary circulation after coronary spasm, THROMB RES, 103(5), 2001, pp. 377-386
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
THROMBOSIS RESEARCH
ISSN journal
0049-3848 → ACNP
Volume
103
Issue
5
Year of publication
2001
Pages
377 - 386
Database
ISI
SICI code
0049-3848(20010901)103:5<377:EPAITC>2.0.ZU;2-C
Abstract
A recently developed platelet aggregometer using a laser light scattering m ethod is capable of monitoring the increase in size of small-sized platelet aggregates (diameter 9-25 mum), which cannot be detected with the conventi onal methods. Whether coronary spasm can cause platelet aggregation in the coronary circulation is unknown. We investigated platelet aggregation, espe cially small-sized platelet aggregates, simultaneously in the coronary sinu s and the aortic root in 18 patients with coronary spastic angina before an d after a left coronary artery spasm induced by intracoronary injection of acetylcholine, and in 15 patients with stable exertional angina before and after acute myocardial ischemia induced by rapid right atrial pacing. Plate let aggregation in 12 patients with chest pain syndrome was also examined b efore and after coronary spasms provoked by acetylcholine. The number of sm all-sized platelet aggregates increased significantly in the coronary sinus [2.0 +/- 0.6 x 10(4) to 4.1 +/- 1.0 x 10(4) (V), P < .01] and in the aorti c root [1.7 +/- 0.6 x 10(4) to 3.2 +/- 0.6 x 10(4) (V), P < .05], and the c oronary sinus-arterial difference in the number of small-sized platelet agg regates [2.3 +/- 1.9 x 10(3) to 1.1 +/- 0.4 x 10(4) (V), P < .01] increased significantly after attacks in the coronary spastic angina group, but rema ined the same in the stable exertional angina group after attacks and in th e chest pain syndrome group after the administration of acetylcholine. Ther efore, we can conclude that acute myocardial ischemia induced by coronary s pasm causes platelet aggregation in the coronary circulation. (C) 2001 Else vier Science Ltd. All rights reserved.