Zinc borohydride reduction of alpha-amino ketones: A highly diastereoselective synthetic route to anti-gamma-hydroxy-beta-amino alcohols

Citation
S. Sengupta et al., Zinc borohydride reduction of alpha-amino ketones: A highly diastereoselective synthetic route to anti-gamma-hydroxy-beta-amino alcohols, SYNLETT, (9), 2001, pp. 1464-1466
Citations number
45
Language
INGLESE
art.tipo
Letter
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
0936-5214 → ACNP
Issue
9
Year of publication
2001
Pages
1464 - 1466
Database
ISI
SICI code
0936-5214(200109):9<1464:ZBROAK>2.0.ZU;2-2
Abstract
A highly diastereoselective synthesis of anti-gamma -hydroxy-beta -amino al cohols via Zn(BH4)(2) reductions of serine derived alpha -amino ketones is described. The latter were prepared from a serine derived gamma -amino-beta -ketosulfone via a alpha -alkylation-desulfonation sequence.