A novel protocol for construction of indolylmethyl group at aldehydes or ketones

Citation
H. Tokuyama et al., A novel protocol for construction of indolylmethyl group at aldehydes or ketones, SYNLETT, (9), 2001, pp. 1403-1406
Citations number
16
Language
INGLESE
art.tipo
Letter
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
0936-5214 → ACNP
Issue
9
Year of publication
2001
Pages
1403 - 1406
Database
ISI
SICI code
0936-5214(200109):9<1403:ANPFCO>2.0.ZU;2-P
Abstract
A new method for introduction of indolylmethyl group to aldehydes or ketone s using diethyl (o-isocyanophenylmethyl)phosphonate through Horner-Wadswort h-Emmons condensation, thiol-mediated radical cyclization, and the subseque nt desulfurization is described. The Horner-Wadsworth-Emmons reagent was pr epared from 2-nitrobenzaldehyde in a concise three-step sequence.