Carcinogenic metals and NF-kappa B activation

Citation
F. Chen et al., Carcinogenic metals and NF-kappa B activation, MOL C BIOCH, 222(1-2), 2001, pp. 159-171
Citations number
110
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cell & Developmental Biology
Journal title
MOLECULAR AND CELLULAR BIOCHEMISTRY
ISSN journal
0300-8177 → ACNP
Volume
222
Issue
1-2
Year of publication
2001
Pages
159 - 171
Database
ISI
SICI code
0300-8177(200106)222:1-2<159:CMANBA>2.0.ZU;2-1
Abstract
Epidemiological and animal studies suggest that several metals and metal-co ntaining compounds are potent mutagens and carcinogens. These metals includ e chromium, arsenic, vanadium, and nickel. During the last two decades, che mical and cellular studies have contributed enormously to our understanding of the mechanisms of metal-induced pathophysiological processes. Although each of these metals is unique in its mechanism of action, some common sign aling molecules, such as reactive oxygen species (ROS), may be shared by ma ny of these carcinogenic metals. New techniques are now available to reveal the mechanisms of carcinogenesis in precise molecular terms. In this revie w, we focused our attentions on metal-induced signal transduction pathways leading to the activation of NF-kappaB, a transcription factor governing th e expression of most early response genes involved in a number of human dis eases.