Combining Drosophila melanogaster somatic-mutation-recombination and electron-spin-resonance-spectroscopy data to interpret epidemiologic observations on chromium carcinogenicity

Citation
Aj. Katz et al., Combining Drosophila melanogaster somatic-mutation-recombination and electron-spin-resonance-spectroscopy data to interpret epidemiologic observations on chromium carcinogenicity, MOL C BIOCH, 222(1-2), 2001, pp. 61-68
Citations number
61
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cell & Developmental Biology
Journal title
MOLECULAR AND CELLULAR BIOCHEMISTRY
ISSN journal
0300-8177 → ACNP
Volume
222
Issue
1-2
Year of publication
2001
Pages
61 - 68
Database
ISI
SICI code
0300-8177(200106)222:1-2<61:CDMSAE>2.0.ZU;2-M
Abstract
Lung cancers are significantly increased among workers exposed to chromate (Crc(6+), Cr3+), chromium pigments (Cr6+) and chromium plating (Cr6+). Chro miun lung burdens and cancer risk increase proportionately with duration of employment at long latencies. However, this epidemiologic information alon e is insufficient in determining whether Cr6+ or Cr3+ are equally important in causing cancer. We have attempted to combine epidemiologic data with da ta from the Drosophila melanogaster somatic-mutation-recombination-test and from the in vitro electron-spin-resonance spectroscopy study to demonstrat e that following somatic recombination plays a more important role than som atic mutation in chromium carcinogenesis. Cr4+ is more important than Cr(5)or Cr6+ in inducing somatic recombination while Cr6+ produces more and big ger clones than Cr4+ in somatic mutation. Cr3+ produces negative results in this fruit-fly wing-spot-assay. When the larvae and flies exposed to Cr6and Cr4+ are examined by ESR, only Cr5+ and Cr3+ are found. Thermodynamic p arameters DeltaE, DeltaH, and DeltaS are also estimated from these latter e xperiments to explain the relative importance of Cr6+, Cr4+, Cr3+ in chromi um carcinogenesis among exposed industrial workers.