In vivo reduction of chromium (VI) and its related free radical generation

Authors
Citation
Kj. Liu et Xl. Shi, In vivo reduction of chromium (VI) and its related free radical generation, MOL C BIOCH, 222(1-2), 2001, pp. 41-47
Citations number
49
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cell & Developmental Biology
Journal title
MOLECULAR AND CELLULAR BIOCHEMISTRY
ISSN journal
0300-8177 → ACNP
Volume
222
Issue
1-2
Year of publication
2001
Pages
41 - 47
Database
ISI
SICI code
0300-8177(200106)222:1-2<41:IVROC(>2.0.ZU;2-I
Abstract
Chromium (VI) compounds are widely recognized as human carcinogens. Extensi ve studies in vitro and in model systems indicate that the reactive interme diate, Cr (V), generated by cellular reduction of Cr (VI), is likely the ca ndidate for the ultimate carcinogenic form of chromium compounds. Here we r eview our current understanding of the in vivo reduction of Cr (VI) and its related free radical generation. Our results demonstrate that Cr (V) is in deed generated from the reduction of Cr (VI) in vivo, and that Cr (V) thus formed can mediate the generation of free radicals. Cr (V) and its related free radicals are very likely to be involved in the mechanism of Cr (VI)-in duced toxicity and carcinogenesis. These studies also illustrate that in vi vo EPR spectroscopy and magnetic resonance imaging can be very useful and p owerful tools for studying paramagnetic metal ions in chemical and biochemi cal reactions occurring in intact animals.