Fish oil (n-3) polyunsaturated fatty acids beneficially affect biliary cholesterol nucleation time in obese women losing weight

Citation
N. Mendez-sanchez et al., Fish oil (n-3) polyunsaturated fatty acids beneficially affect biliary cholesterol nucleation time in obese women losing weight, J NUTR, 131(9), 2001, pp. 2300-2303
Citations number
36
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Food Science/Nutrition","Endocrinology, Nutrition & Metabolism
Journal title
JOURNAL OF NUTRITION
ISSN journal
0022-3166 → ACNP
Volume
131
Issue
9
Year of publication
2001
Pages
2300 - 2303
Database
ISI
SICI code
0022-3166(200109)131:9<2300:FO(PFA>2.0.ZU;2-W
Abstract
It has been reported that intake of (n-3) polyunsaturated fatty acids (PUFA ) reduces the risk of coronary heart disease and decreases biliary choleste rol saturation in the bile of gallstone patients. We investigated the effec t of n-3 PUFA on cholesterol saturation index (CSI) and nucleation time (NT ) in obese subjects who were losing weight. This was a double-blind, placeb o-controlled clinical trial. Obese women (n = 35) with a body mass index (B MI) greater than or equal to 30 kg/m(2), with no prior history of gallstone s or cholecystectomy by ultrasound were first studied to ensure absence of stones or biliary sludge. The women were then assigned to a hypocaloric reg imen [5.02 MJ (1200 kcal)/d] and to receive 1200 mg/d of ursodeoxycholic ac id (UDCA), 11.3 g/d of (n-3) PUFA or a placebo for 6 wk. BMI, CSI and NT we re recorded at baseline and at the end of the experimental period. BMI decr eased 5.75 +/- 2.7%/mo (range, 1.5-12.42%/mo) during the experiment. The CS I did not change in any of the groups. Cholesterol NT decreased significant ly in the UDCA and placebo groups, but not in the (n-3) PUFA group. None of the women had developed gallstones at 6 wk. These results suggest that (n- 3) PUFA maintain the CSI and NT in obese women during rapid weight loss, wh ich probably results in the prevention of cholesterol gallstone formation.