S. Oda et al., Preparation of methyl ursodeoxycholate in an interface bioreactor: Use of a mixed solvent system to increase the solubilities of substrate and product, J BIOSCI BI, 92(1), 2001, pp. 86-88
A mixed solvent system was used as the reaction solvent of an interface bio
reactor for the first time. The solvent, dodecane/2-ethylhexyl acetate (4:6
), exhibited excellent efficiency in the preparation of methyl ursodeoxycho
late with Eubacterium aerofaciens JCM 7790.