Increased body weight in C57BL/6 female mice after exposure to ionizing radiation or 60 Hz magnetic fields

Citation
Jt. Babbitt et al., Increased body weight in C57BL/6 female mice after exposure to ionizing radiation or 60 Hz magnetic fields, INT J RAD B, 77(8), 2001, pp. 875-882
Citations number
32
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Experimental Biology
Journal title
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
ISSN journal
0955-3002 → ACNP
Volume
77
Issue
8
Year of publication
2001
Pages
875 - 882
Database
ISI
SICI code
0955-3002(200108)77:8<875:IBWICF>2.0.ZU;2-A
Abstract
Purpose: The purpose of this investigation was to determine whether early t reatment with ionizing radiation and/or chronic magnetic field (MF) exposur e affected body weight in female mice. Materials and methods: Weanling C57BL/6 female mice were irradiated with fo ur equal weekly cobalt-60 exposures (total cumulative closes: 3.0, 4.0, 5.1 Gy) and/or received chronic lifetime exposure to 1.4mT 60Hz circularly pol arized MF or ambient MF. The body weights of 2280 mice were recorded at 35 age intervals, and analysis of variance was used to compare the mean differ ences from baseline weights between treatment groups and sham-exposed contr ols. Results: A highly statistically significant effect of ionizing radiation on body Weight was observed at 28 age intervals (p less than or equal to0.001 ), and for MF exposure at 10 age intervals (p less than or equal to0.001). During the young adult growth phase, mice exposed only to MF exhibited less than or equal to0.5g greater weight gain relative to sham-exposed controls (p=0.0001). The effect of ionizing radiation alone was inversely related t o close, with the largest weight increases observed in all of the irradiate d groups after 9-12 months (p=0.0001). Conclusions: Treatment with split-dose ionizing radiation at an early age a nd chronic exposure to a residential power frequency NIF were Found to prod uce small but significant increases in body weight.