Synthesis and hybridization properties of thiazolidine PNAs

Citation
S. Bregant et al., Synthesis and hybridization properties of thiazolidine PNAs, EUR J ORG C, (17), 2001, pp. 3285-3294
Citations number
46
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
ISSN journal
1434-193X → ACNP
Issue
17
Year of publication
2001
Pages
3285 - 3294
Database
ISI
SICI code
1434-193X(200109):17<3285:SAHPOT>2.0.ZU;2-X
Abstract
Two new, constrained PNA monomers, each containing a thiazolidine ring, wer e synthesized and incorporated into a central position in a PNA. It was sho wn by UV melting experiments that the presence of a single constrained unit does not prevent the cooperative association of the PNA but does significa ntly destabilize PNA/DNA and PNA/RNA triplexes.