Cone voltage and collision cell collision-induced dissociation study of triphenylethylenes of pharmaceutical interest

Citation
J. Makowiecki et al., Cone voltage and collision cell collision-induced dissociation study of triphenylethylenes of pharmaceutical interest, RAP C MASS, 15(17), 2001, pp. 1506-1513
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
ISSN journal
0951-4198 → ACNP
Volume
15
Issue
17
Year of publication
2001
Pages
1506 - 1513
Database
ISI
SICI code
0951-4198(2001)15:17<1506:CVACCC>2.0.ZU;2-S
Abstract
Fragmentations of three triphenylethylene compounds (toremifene and its two metabolites) with different functional side-chain groups (alcohol, acid an d amine) were studied. The compounds were dissociated by collision-induced dissociation (CID) in the interface region of an electrospray ionization so urce (ESI+) and in the collision cell of a triple quadrupole mass spectrome ter. Fragmentation pathways for these molecules are proposed, based on accu rate mass measurements of in-source fragment ions and MS/MS experiments usi ng product and precursor ion scanning. The side-chain functional groups wer e found to strongly affect the fragmentations of the molecular ions. The fr agmentation pathways of the protonated molecule and sodium ion adduct were quite similar, but the subsequent stabilities of certain common fragments w ere surprisingly different. Copyright (C) 2001 John Wiley & Sons, Ltd.