The TRP53 pathway is induced in vivo by low doses of gamma radiation

Citation
De. Maccallum et al., The TRP53 pathway is induced in vivo by low doses of gamma radiation, RADIAT RES, 156(3), 2001, pp. 324-327
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Experimental Biology
Journal title
RADIATION RESEARCH
ISSN journal
0033-7587 → ACNP
Volume
156
Issue
3
Year of publication
2001
Pages
324 - 327
Database
ISI
SICI code
0033-7587(200109)156:3<324:TTPIII>2.0.ZU;2-G
Abstract
The induction of the Trp53 response after very low doses (0.01-1 Gy) of ion izing radiation was studied in the adult mouse using immunochemical and imm unohistochemical methods. We found a detectable response at 0.01 Gy and an increased induction of Trp53 with increasing dose in both radiation-resista nt and radiation-sensitive tissues. These results suggest that there is no lower threshold for induction. This response was heterogeneous, since cells that received the same dose had different staining intensities, suggesting that the induction of Trp53 is not based simply on dose-dependent response s to DNA damage. These data also demonstrate the exquisite sensitivity of t he Trp53 pathway and show that this response is controlled by cell- and tis sue-specific factors that have yet to be defined. (C) 2001 by Radiation Res earch Society.