The changes in the expressions of gamma-aminobutyric acid transporters in the gerbil hippocampal complex following spontaneous seizure

Citation
Tc. Kang et al., The changes in the expressions of gamma-aminobutyric acid transporters in the gerbil hippocampal complex following spontaneous seizure, NEUROSCI L, 310(1), 2001, pp. 29-32
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROSCIENCE LETTERS
ISSN journal
0304-3940 → ACNP
Volume
310
Issue
1
Year of publication
2001
Pages
29 - 32
Database
ISI
SICI code
0304-3940(20010907)310:1<29:TCITEO>2.0.ZU;2-6
Abstract
To identify the roles of gamma -aminobutyric acid (GABA) transporter in epi leptogenesis and the recovery mechanisms in spontaneous seizure, a chronolo gical and comparative analysis of GABA transporters (GAT) expression was co nducted. GAT-1 immunoreactivity was more strongly detected in the pre-seizu re group of seizure sensitive (SS) gerbils than that seen in the seizure re sistant group. 30 min postictal, the density of GAT-1 immunoreactivity was significantly decreased in the hippocampal complex, as compared to pre-seiz ure group. 12 h after seizure on-set, the GAT immunodensity recovered to th e pre-seizure level. Following the onset of seizure, GAT-3 immunoreactivity remained unchanged. These results suggest that the increase of GAT-1 expre ssion in the SS gerbil hippocampus may affect epileptogenesis in this anima l, and the alteration of immunoreactivity following seizure may be compensa tory responses to modulate seizure activity. (C) 2001 Elsevier Science Irel and Ltd. All rights reserved.