Biochemical, histological and behavioral consequences of nephrectomy in young and aged mice

Citation
M. Al Banchaabouchi et al., Biochemical, histological and behavioral consequences of nephrectomy in young and aged mice, NEPHRON, 89(1), 2001, pp. 90-100
Citations number
46
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Urology & Nephrology","da verificare
Journal title
NEPHRON
ISSN journal
0028-2766 → ACNP
Volume
89
Issue
1
Year of publication
2001
Pages
90 - 100
Database
ISI
SICI code
0028-2766(200109)89:1<90:BHABCO>2.0.ZU;2-S
Abstract
Background: This study investigates the effect of nephrectomy in young and aged mice on some biochemical, histological and behavioural aspects. Method s: Each age group, 2- and 12-months-old, comprised a sham-operated group, a unilaterally nephrectomized group and a subtotally nephrectomized group. C onsequences of nephrectomy were examined 10 days postsurgery on urea and gu anidino compound levels in body fluids and brain; the remaining kidney by l ight-microscopic examination; and learning and memory abilities using the M orris water maze task. Results: Effect of nephrectomy on urea and guanidino compound levels in plasma, urine and brain was significantly more pronounc ed in the young age group. Some guanidino compounds show a tendency to decr ease with aging in the sham-operated group and the two nephrectomized group s. Higher compensatory kidney hypertrophy was found in younger nephrectomiz ed mice whereas in older mice glomerular mesangial expansion was a common f eature. Finally, young mice with subtotal nephrectomy displayed a slight bu t significant impairment in memory and learning; whilst old nephrectomized mice manifested no impairment. Conclusions: Nephrectomy induces more change s in younger mice than in older mice as observed in higher variation of ure a and guanidino compound levels, glomerular volume and kidney hypertrophy a nd decline in spatial learning and memory. Copyright (C) 2001 S. Karger AG, Basel.