Genetic variations in five genes involved in the excitement of cardiomyocytes

Citation
H. Iwasa et al., Genetic variations in five genes involved in the excitement of cardiomyocytes, J HUM GENET, 46(9), 2001, pp. 549-552
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Molecular Biology & Genetics
Journal title
JOURNAL OF HUMAN GENETICS
ISSN journal
1434-5161 → ACNP
Volume
46
Issue
9
Year of publication
2001
Pages
549 - 552
Database
ISI
SICI code
1434-5161(2001)46:9<549:GVIFGI>2.0.ZU;2-Z
Abstract
We provide here 29 genetic variations, including 28 novel ones, in five gen es that are potentially involved in the excitement of cardiomyocytes: we fo und 4 in KCNA10, 2 in KCNK1, 8 in KCNK6, 11 in SLC18A1 (VMAT1), and 4 in SL C6A2 (norepinephrine transporter). We also examined their allelic frequenci es in a Japanese population of long QT syndrome-affected and nonaffected in dividuals. These data would be useful for genetic association studies desig ned to investigate acquired arrhythmias.