Objective: To evaluate the effects of Hachimi-jio-gan, a traditional Japane
se Kampo medication composed of eight medicinal herbs used for treating old
Subjects: Sixteen laboratory-bred Fischer 344 rats
Design: The rats were divided into two groups. One was the control group an
d the other was given chow containing 7% Hachimi-jio-gan powder for a perio
d 110-120 weeks.
Outcome measures: The rats were assessed for wheel running and an inclined
screen test from weeks 119-120; then laboratory and histologic examinations
Results: The group receiving Hachimi-jio-gan was more active in spontaneous
mobility during wheel running; they maintained a significantly higher angl
e of retaining posture than the control group on the inclined screen; there
was no significant difference in laboratory and histologic findings.
Conclusions: Aged rats that received Hachimi-jio-gan were more active and s
tronger than the control group rats. The findings suggest that Hachimi-jio-
gan is a safe and effective Kampo prescription for aging rats.