Effects of Hachimi-Jio-Gan in aged rats

Citation
H. Ninomiya et al., Effects of Hachimi-Jio-Gan in aged rats, J ALTERN C, 7(4), 2001, pp. 355-359
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Health Care Sciences & Services
Journal title
JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
ISSN journal
1075-5535 → ACNP
Volume
7
Issue
4
Year of publication
2001
Pages
355 - 359
Database
ISI
SICI code
1075-5535(200108)7:4<355:EOHIAR>2.0.ZU;2-#
Abstract
Objective: To evaluate the effects of Hachimi-jio-gan, a traditional Japane se Kampo medication composed of eight medicinal herbs used for treating old er people. Subjects: Sixteen laboratory-bred Fischer 344 rats Design: The rats were divided into two groups. One was the control group an d the other was given chow containing 7% Hachimi-jio-gan powder for a perio d 110-120 weeks. Outcome measures: The rats were assessed for wheel running and an inclined screen test from weeks 119-120; then laboratory and histologic examinations were performed. Results: The group receiving Hachimi-jio-gan was more active in spontaneous mobility during wheel running; they maintained a significantly higher angl e of retaining posture than the control group on the inclined screen; there was no significant difference in laboratory and histologic findings. Conclusions: Aged rats that received Hachimi-jio-gan were more active and s tronger than the control group rats. The findings suggest that Hachimi-jio- gan is a safe and effective Kampo prescription for aging rats.