Neuroprotective adaptations in hibernation: Therapeutic implications for ischemia-reperfusion, traumatic brain injury and neurodegenerative diseases

Citation
Kl. Drew et al., Neuroprotective adaptations in hibernation: Therapeutic implications for ischemia-reperfusion, traumatic brain injury and neurodegenerative diseases, FREE RAD B, 31(5), 2001, pp. 563-573
Citations number
151
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Biochemistry & Biophysics
Journal title
FREE RADICAL BIOLOGY AND MEDICINE
ISSN journal
0891-5849 → ACNP
Volume
31
Issue
5
Year of publication
2001
Pages
563 - 573
Database
ISI
SICI code
0891-5849(20010901)31:5<563:NAIHTI>2.0.ZU;2-0
Abstract
Brains of hibernating mammals are protected against a variety of insults th at are detrimental to humans and other nonhibernating species. Such protect ion is associated with a number of physiological adaptations including hypo thermia, increased antioxidant defense, metabolic arrest, leukocytopenia, i mmunosuppression, and hypocoagulation. It is intriguing that similar manipu lations provide considerable protection as experimental treatments for cent ral nervous system injury. This review focuses on neuroprotective mechanism s employed during hibernation that may offer novel approaches in the treatm ent of stroke, traumatic brain injury, and neurodegenerative diseases in hu mans. (C) 2001 Elsevier Science Inc.