B. Horan et al., The selective sigma(1) receptor agonist, 1-(3,4-dimethoxyphenethyl)-4-(phenylpropyl) piperazine (SA4503), blocks the acquisition of the conditioned place preference response to (-)-nicotine in rats, EUR J PHARM, 426(1-2), 2001, pp. R1-R2
We examined the effect of the sigma (1) receptor agonist, 1-(3,4-dimethoxyp
henethyl)-4-(phenylpropyl)piperazine (SA4503), on the acquisition of the co
nditioned place preference response to subcutaneously administered (-)-nico
tine in rats. (-)-Nicotine, but not SA4503 or vehicle, produced a significa
nt conditioned place preference response. Pretreatment of animals with eith
er 1 or 3 mg/kg of SA4503 significantly attenuated the conditioned place pr
eference response to)-nicotine. (C) 2001 Published by Elsevier Science B.V.