Specific antimicrobial synergism of synthetic hydroxy isothiocyanates withaminoglycoside antibiotics

Citation
H. Tajima et al., Specific antimicrobial synergism of synthetic hydroxy isothiocyanates withaminoglycoside antibiotics, BIOS BIOT B, 65(8), 2001, pp. 1886-1888
Citations number
10
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Biochemistry & Biophysics
Journal title
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
ISSN journal
0916-8451 → ACNP
Volume
65
Issue
8
Year of publication
2001
Pages
1886 - 1888
Database
ISI
SICI code
0916-8451(200108)65:8<1886:SASOSH>2.0.ZU;2-C
Abstract
Hydroxy isothiocyanates, especially 2-(4-hydroxyphenyl)ethyl isothiocyanate (hITC), were examined for antimicrobial synergism with several antibiotics against Escherichia coli and Staphylococcus aureus, using a multiwell plat e system. hITC had antibacterial synergism, specifically with aminoglycosid e antibiotics. The synergism was observed in synthetic medium (M9 minimal m edium) or soybean casein digest broth,, but not in nutrient broth. Synergis m was seen in the presence of certain sugars such as glucose, fructose, and maltose in the medium.