bcl2, p53 and bax in thyroid tumors and their relation to apoptosis

Citation
P. Farid et al., bcl2, p53 and bax in thyroid tumors and their relation to apoptosis, NEOPLASMA, 48(4), 2001, pp. 299-301
Citations number
12
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
NEOPLASMA
ISSN journal
0028-2685 → ACNP
Volume
48
Issue
4
Year of publication
2001
Pages
299 - 301
Database
ISI
SICI code
0028-2685(2001)48:4<299:BPABIT>2.0.ZU;2-U
Abstract
Twenty five thyroid tumors were investigated by immunohistochemistry for th e presence of apoptosis, expression of p53, bax and bcl(2). In nine adenoma s (average age 40) the rate of p53 positive cells was 5.7%, while it was 13 .3% for bax and 41.7% for bcl(2) in the tumor cells. In six follicular carc inomas (average age 56) p53 positivity was obtained for 71.1%, while bax an d bcl(2) positivity constituted 3.4 to and 2.5 to, respectively. In ten pap illary adenocarcinomas (average age 42) p53 was positive in 39.6%, but bax and bcl(2) were positive in 3.4% and 3% of the tumor cells, respectively. A lmost no signs of spontaneous apoptosis were found in any of the cases. Det ermination of p53, bax and bcl(2) ratio in thyroid tumors may contribute to the differentiation between follicular adenomas and carcinomas.