Multiple granulocytic sarcomas in acute myeloblastic leukemia with simultaneous occurrence of t(8 : 21) and trisomy 8

Citation
S. Somjee et al., Multiple granulocytic sarcomas in acute myeloblastic leukemia with simultaneous occurrence of t(8 : 21) and trisomy 8, LEUK LYMPH, 42(5), 2001, pp. 1139-1144
Citations number
28
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology,"Onconogenesis & Cancer Research
Journal title
LEUKEMIA & LYMPHOMA
ISSN journal
1042-8194 → ACNP
Volume
42
Issue
5
Year of publication
2001
Pages
1139 - 1144
Database
ISI
SICI code
1042-8194(200109/10)42:5<1139:MGSIAM>2.0.ZU;2-K
Abstract
This report describes a rare case of multiple intracranial, extradural chlo romas. A five year old African American male presented with headache, fever , and vomiting. The peripheral blood smear showed myeloblasts with Auer rod s. The CTscan of the brain showed three intracranial, epidural lesions as w ell as soft tissue masses in the retroorbital region and sphenoid sinuses. CTscan of the chest showed two paraspinal epidural thoracic masses. Patholo gy of the epidural intracranial mass revealed a granulocytic sarcoma. Cytog enetic analysis showed simultaneous occurrence of t (8;21) and trisomy 8. F ollowing induction therapy, he is now in complete remission.