Mediators for fat-induced ileal brake are different between stomach and proximal small intestine in conscious dogs

Citation
N. Ohtani et al., Mediators for fat-induced ileal brake are different between stomach and proximal small intestine in conscious dogs, J GASTRO S, 5(4), 2001, pp. 377-382
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Surgery
Journal title
JOURNAL OF GASTROINTESTINAL SURGERY
ISSN journal
1091-255X → ACNP
Volume
5
Issue
4
Year of publication
2001
Pages
377 - 382
Database
ISI
SICI code
1091-255X(200107/08)5:4<377:MFFIBA>2.0.ZU;2-4
Abstract
Our aim was to determine the mechanisms by which intraileal fat alters prox imal gastrointestinal motility-the ileal brake. Five mongrel dogs with ilea l Thiry-Vella fistulas were equipped with strain gauge force transducers on the upper gut to measure contractile activity. Ileal infusions of 115 mmol /L oleic acid and triglyceride were studied in dogs with extrinsically inne rvated and extrinsically denervated Thiry-Vella loops. Plasma concentration s of peptide YY and total glucagon-like immunoactivity were measured. Oleic acid but not triglyceride inhibited postprandial contractions in the gastr ic antrum in dogs with innervated and denervated Thiry-Vella loops. Postpra ndial duodenal and jejunal motility was inhibited by oleic acid regardless of extrinsic denervation to the loops (P <0.05), but triglyceride inhibited small intestinal motility only in dogs with innervated Thiry-Vella loops. Intraileal oleic acid but not triglyceride increased plasma concentrations of peptide YY and total glucagon-like immunoactivity in dogs with innervate d and denervated Thiry-Vella loops. Intraileal oleic acid inhibits gastric and small intestinal motility possibly via increased plasma concentrations of peptide YY and enteroglucagon. Intact extrinsic innervation is necessary for intraileal triglyceride to inhibit small intestinal motility.