Recently, two new ligands of the Arp2/3 complex have been described that ma
y shed light on the way cells organize complex networks of actin in respons
e to signals. Abp1p, a yeast protein involved in endocytosis, and cortactin
, a mammalian sic substrate, both enhance the ability of the Arp2/3 complex
to assemble branched actin filament networks.