Effects of smoking on myocardial injury in patients with conservatively treated acute myocardial infarction - A study with resting I-123-15-iodophenyl 3-methyl pentadecanoic acid/Tl-201 myocardial single photon emission computed tomography

Citation
H. Yamagishi et al., Effects of smoking on myocardial injury in patients with conservatively treated acute myocardial infarction - A study with resting I-123-15-iodophenyl 3-methyl pentadecanoic acid/Tl-201 myocardial single photon emission computed tomography, JPN CIRC J, 65(9), 2001, pp. 769-774
Citations number
38
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION
ISSN journal
0047-1828 → ACNP
Volume
65
Issue
9
Year of publication
2001
Pages
769 - 774
Database
ISI
SICI code
0047-1828(200109)65:9<769:EOSOMI>2.0.ZU;2-P
Abstract
Many reports have demonstrated that smokers who have suffered an acute myoc ardial infarction (AMI) have a better prognosis than nonsmokers. The presen t study investigated the effects of current smoking on myocardial injury wi th resting I-123-15-iodophenyl 3-methyl pentadecanoic acid (BMIPP)/Tl-201 m yocardial single photon emission computed tomography in 103 patients with c onservatively treated AMI. The left ventricular myocardium was divided into 9 segments and BMIPP and 201TI defects were scored using a 5-point grading system (0=normal and 4=no uptake). The sum of the defect scores was define d as the total defect score. There was no significant difference in either the baseline severity of the coronary artery disease or the total defect sc ores for BMIPP and Tl-201 between the current smoker and nonsmoker groups. The difference between the total defect scores for BMIPP and Tl-201 tended to be larger in the current smoker group than in the nonsmoker group (2.0 /-1.9 vs 1.3 1.6, p=0.056). Forty-one (53%) of 77 patients in the current s moker group exhibited a BMIPP/Tl-201 mismatch, whereas only 8 (31%) of 26 p atients in the nonsmoker group did (p=0.047). In conclusion, current smoker s had more likelihood of salvageable myocardium in areas at risk, as demons trated by BMIPP/Tl-201 mismatch, in AMI than nonsmokers.