Significance of serum matrix metalloproteinases and their inhibitors on the antifibrogenetic effect of interferon-alfa in chronic hepatitis C patients

Citation
T. Ninomiya et al., Significance of serum matrix metalloproteinases and their inhibitors on the antifibrogenetic effect of interferon-alfa in chronic hepatitis C patients, INTERVIROLO, 44(4), 2001, pp. 227-231
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Microbiology
Journal title
INTERVIROLOGY
ISSN journal
0300-5526 → ACNP
Volume
44
Issue
4
Year of publication
2001
Pages
227 - 231
Database
ISI
SICI code
0300-5526(200107/08)44:4<227:SOSMMA>2.0.ZU;2-2
Abstract
Objective and Methods: The imbalance between matrix metalloproteinases (MMP s) and tissue inhibitors of matrix metalloproteinases (TIMPs) is considered to be an important determination of deposition and breakdown of the extrac ellular matrix. To investigate the antifibrogenetic effect of interferon-al pha (IFN-alpha) treatment on factors regulating hepatic fibrosis, serum MMP -1, MMF-2, TIMP-1 and TIMP-2 levels were measured by the one-step sandwich enzyme immunoassay in 27 patients with chronic hepatitis C and compared wit h the histological status of the patients before and at the end of treatmen t. Results: After 6 months of IFN-alpha treatment, the histological status of liver fibrosis showed improvement in 9 patients (IF group) and no change or a worsening in 18 patients (NIF group). Compared with pretreatment leve ls, in the IF group, IFN treatment caused a significant increase in the MMP -1/TIMP-1 ratio. In the NIF group, however, the MMP-1/TIMP-1 ratio tended t owards a decrease; moreover, there was not only a significant increase in T IMP-2 levels but also a tendency towards an increase in TIMP-1 levels. Conc lusion: These results suggested that an elevated MMP-1/TIMP-1 ratio may ame liorate liver fibrosis by interferon in cases of chronic hepatitis C, where as elevated levels of TIMP-1 and TIMP-2 might impede improvement. Copyright (C) 2001 S. Karger AG, Basel.