Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene

Citation
M. Kimura et al., Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene, IMMUNITY, 15(2), 2001, pp. 275-287
Citations number
68
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
IMMUNITY
ISSN journal
1074-7613 → ACNP
Volume
15
Issue
2
Year of publication
2001
Pages
275 - 287
Database
ISI
SICI code
1074-7613(200108)15:2<275:ROTCDB>2.0.ZU;2-V
Abstract
Polycomb group (PcG) gene products regulate homeobox gene expression in Dro sophila and vertebrates and also cell cycle progression of immature lymphoc ytes. In a gene-disrupted mouse for polycomb group gene mel-18, mature peri pheral T cells exhibited normal anti-TCR-induced proliferation; however, th e production of Th2 cytokines (IL-4, IL-5, and IL-13) was significantly red uced, whereas production of IFN gamma was modestly enhanced. Th2 cell diffe rentiation was impaired, and the defect was associated with decreased level s in demethylation of the IL-4 gene. Significantly, reduced GATA3 induction was demonstrated. In vivo antigen-induced IgG1 production and Nippostrongy lus brasiliensis-induced eosinophilia were significantly affected, reflecti ng the deficit in Th2 cell differentiation. Thus, the PcG gene products pla y a critical role in the control of Th2 cell differentiation and Th2-depend ent immune responses.