Are there histopathologic characteristics particular to fulminant hepatic failure caused by human herpesvirus-6 infection? A case report and discussion

Citation
K. Aita et al., Are there histopathologic characteristics particular to fulminant hepatic failure caused by human herpesvirus-6 infection? A case report and discussion, HUMAN PATH, 32(8), 2001, pp. 887-889
Citations number
12
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research Diagnosis & Treatment
Journal title
HUMAN PATHOLOGY
ISSN journal
0046-8177 → ACNP
Volume
32
Issue
8
Year of publication
2001
Pages
887 - 889
Database
ISI
SICI code
0046-8177(200108)32:8<887:ATHCPT>2.0.ZU;2-B
Abstract
An 8-month-old boy was admitted to a neighboring hospital for severe liver dysfunction and drowsiness 4 days after a diagnosis of exanthem subitun. A diagnosis of fulminant hepatic failure was made, and liver biopsy was perfo rmed during the acute stage. The presence of human herpesvirus-6 variant B (HHV-6B) DNA was shown in liver tissue by polymerase chain reaction (PCR) a nd in the endothelium of the portal vein by in situ hybridization (ISH). Hi stologic examination showed microvesicular steatosis resembling that of Rey e's syndrome, even though aspirin had not been prescribed. We considered HH V-6 to be the causative agent in this case and report what is perhaps the f irst precise histologic description of fulminant hepatic failure caused by HHV-6. HUM PATHOL 32:887-889. (C) 2001 by W.B. Saunders Company.