Enhanced associated movements in the contralateral limbs elicited by briskvoluntary contraction in choreic disorders

Citation
T. Hashimoto et al., Enhanced associated movements in the contralateral limbs elicited by briskvoluntary contraction in choreic disorders, CLIN NEU, 112(9), 2001, pp. 1612-1617
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
CLINICAL NEUROPHYSIOLOGY
ISSN journal
1388-2457 → ACNP
Volume
112
Issue
9
Year of publication
2001
Pages
1612 - 1617
Database
ISI
SICI code
1388-2457(200109)112:9<1612:EAMITC>2.0.ZU;2-F
Abstract
Objectives: To study the deficit of inhibition of excessive motor drive gen erated in the central nervous system in chorea. Methods: Identical associated movements in the contralateral limb elicited by rapid hand squeezing were measured in 6 patients with Huntington's disea se, 7 patients with peak-dose dyskinesia, 10 patients with Parkinson's dise ase, 8 patients with spinocerebellar degeneration and in 8 normal subjects. The intensity of associated movements was assessed by the EMG amplitude ra tio of associated contractions to active contractions. Results: The associated movement ratios were larger in Huntington's disease and peak-dose dyskinesia as compared to other groups. The ratios in akinet ic 'off' phase were smaller than those in dyskinetic 'on' phase in all peak -dose dyskinesia patients. Conclusions: Enhanced associated movements support a possible common mechan ism that chorea may result from failure in inhibition of phasic neural acti vity pathologically generated in the brain. (C) 2001 Elsevier Science Irela nd Ltd. All rights reserved.