Maternal energy stores and diet composition during pregnancy program adolescent blood pressure

Citation
Ls. Adair et al., Maternal energy stores and diet composition during pregnancy program adolescent blood pressure, CIRCULATION, 104(9), 2001, pp. 1034-1039
Citations number
23
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
CIRCULATION
ISSN journal
0009-7322 → ACNP
Volume
104
Issue
9
Year of publication
2001
Pages
1034 - 1039
Database
ISI
SICI code
0009-7322(20010828)104:9<1034:MESADC>2.0.ZU;2-E
Abstract
Background-Fetal undernutrition is hypothesized to program blood pressure ( BP) later in life. Human epidemiological studies that use birth weight as a proxy for fetal malnutrition fail to identify specific aspects of maternal nutrition responsible, for programming. Methods, and Results-We examined how maternal nutrition during pregnancy an d infant birth weight relate to systolic and diastolic BP (SBP and DBP) in 2026 Filipino adolescents. Data were collected prospectively during the Ceb u (Philippines) Longitudinal Health and Nutrition Survey. Women were assess ed at approximate to 30 weeks gestation, and children were followed from bi rth through adolescence. Regression models were used to examine how the mot hers' total energy intake, percentage of energy from protein and fat, trice ps skinfold thickness during pregnancy, and infant birth weight relate to a dolescent BP, controlling for current age, height, and body mass index and other potential confounders. Maternal triceps skinfold thickness was signif icantly inversely related to SBP among boys and to DBP in boys and girls. M aternal nutrition variables attenuated but did not eliminate an inverse bir th weight-SBP relationship in boys. SBP was significantly inversely related to the mothers' percent of dietary energy from protein in boys. Among girl s, SBP and DBP were inversely related to the mothers' percentage of calorie s from fat. There was no evidence of confounding of these relationships by current diet, maturation status, physical activity, or socioeconomic status . Conclusions-Maternal diet composition and energy stores in the form of subc utaneous fat have long-term effects on offspring BP in adolescence.