beta(3)-Adrenoceptor is involved in the inhibition of small intestinal motility due to restraint stress in rats

Authors
Tsukada, F Sugawara, M Sawamura, K Ohuchi, Y Kohno, H Ohkubo, Y
Citation
F. Tsukada et al., beta(3)-Adrenoceptor is involved in the inhibition of small intestinal motility due to restraint stress in rats, BIOL PHAR B, 24(9), 2001, pp. 995-997
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
BIOLOGICAL & PHARMACEUTICAL BULLETIN
ISSN journal
0918-6158 → ACNP
Volume
24
Issue
9
Year of publication
2001
Pages
995 - 997
Database
ISI
SICI code
0918-6158(200109)24:9<995:BIIITI>2.0.ZU;2-T
Abstract
We have reported that acute restraint stress inhibits small intestinal moti lity in rats. In order to clarify this inhibitory mechanism, we examined th e effects of alpha- and beta -adrenergic antagonists on the inhibition of s mall intestinal motility induced by restraint stress. This inhibition under went recovery by propranolol (beta (1)/beta (2)-antagonist) or SR59230A (be ta (3)-antagonist), but not by atenolol (beta (1)-antagonist), ICI-118,551 (beta (2)-antagonist), prazosin (a,antagonist) or yohimbine (alpha (2)-anta gonist). These results suggest that beta (3)-adrenoceptors play an importan t role in the inhibition of small intestinal motility caused by restraint s tress.